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L/2/12

MAŁGORZATA ŚWIDER-AL-AMAWI

REGULATION OF STEROIDOGENESIS IN RAT EPIDIDYMAL EPITHELIAL
CELLS

Summary
The epididymal epithelial cells of rats in vitro display features of steroidogenic cells. The cells produce and release androgens into the culture medium that are converted to 17β-estradiol (E2) due to the activity of cytochrome P450 aromatase. It is probable that steroidogenesis in epididymal epithelial cells of rat is regulated by luteinizing hormone (LH). The aim of the study was to estimate the in.uence of hCG on the morphology of epididymal epithelial cells and synthesis of E2 by the cells. In conclusion, the hCG stimulation results in changes of the cell morphology, similar to those observed in Leydig cells and increase synthesis of the 17β-estradiol due to the presence of LH/hCG receptors.

K e y w o r d s : epididymis - steroidogenesis - human chorionic gonadotropin.
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