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2005; 51, 1, 13-21

TARIQ AL-AMAWI

COMPARATIVE STUDY OF PROGNOSTIC FACTORS IN PATIENTS SUBJECTED TO RADICAL SURGERY FOR RECTAL CANCER AT CLINICAL STAGE T2 OR T3

Oddział Kliniczny Chirurgii Onkologicznej Pomorskiej Akademii Medycznej
al. Powstańców Wlkp. 72, 70-111 Szczecin
Kierownik: dr hab. n. med. Józef Kładny

Summary
Purpose: The aim of the study was to evaluate and compare some prognostic factors for rectal cancer in clinical stage T2 and T3.
Material and methods: Patients and methods: 174 consecutive patients with T3 stage tumors and 112 patients with T2 stage tumors were enrolled. Patients underwent curative resection for rectal cancer between January 1993 and December 1997 in eight hospitals of Szczecin. Kaplan–Meier survival analysis was used to determine survival rates. Significance was checked with the log-rank test. Multivariate analyses were adjusted using Cox proportional hazard models.
Results: No significant differences in morbidity and mortality between the studied groups were observed. Postoperative surgical complications were found in 30 patients with T3 stage tumors (17.2%) and 15 patients (13.4%) with T2 stage tumors. Overall five-year survival was higher in patients with T2 stage tumors (56%) than in patients with T3 stage tumors (40%) and local recurrence was observed in 13.9% and 16.7% of the patients, respectively. Multivariate analysis showed that grade, lymph node involvement, local recurrence, surgeon’s experience, postoperative complications, inadvertent perforation of tumor, and adjuvant chemotherapy had a significant effect on survival in T3 stage tumors. In T2 stage tumors, survival was influenced by grade and local recurrence.
Conclusion: Comparative analysis showed that clinical and p athological factors were of great importance for prognostication in the more advanced T3 stage, whereas clinical factors had no value in T2 stage.

K e y w o r d s: rectal cancer - prognostic factors - T2 stage - T3 stage.
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