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Ann Acad Med Stetin, 2006; 52, 3, 15-23

IWONA POZIOMKOWSKA-GĘSICKA

 

BRONCHI REACTION TO THE INHALED SALBUTAMOL ACCORDING TO THE POLYMORPHISMS OF β2-ADRENERGIC RECEPTOR

Katedra i Zakład Fizjologii Pomorskiej Akademii Medycznej

al. Powstańców Wlkp. 72, 70-111 Szczecin

Kierownik: prof. dr hab. n. med. Andrzej Paradowski

 

Summary

Introduction: The functioning of β2-adrenergic receptor (β2ADR) depends on its isoforms. Polymorphism of the β2ADR gene has been described, the most frequent being g.46A→G and g.79C→G. The reaction of the bronchi to inhaled salbutamol has now been studied in relation to g.46A→G and g.79C→G polymorphisms. For this purpose, spirometry was done in healthy males aged 20–26 years.

Material and methods: The study group comprised 170 young men who were allocated to six groups according to the β2ADR genotype determined with PCR: g.46A→G polymorphism (g.46AA, g.46GG, g.46AG), g.79C→G polymorphism (g.79CC, g.79GG, g.79GC). Spirometric parameters were measured before and after inhalation of salbutamol. The results of the test were compared in g.46A→G groups and g.79C→G groups.

Results: Administration of 200 μg of salbutamol significantly increased spirometrc parameters during forced expiration. However, changes were not specific for any genotype. Increase in PEF was significantly higher in g.46AA than g.46GG and in g.79CC than g.79GC genotypes. The distribution of genotypes was typical for the Caucasian population.

K e y w o r d s: β2-adrenergic receptor – gene polymorphism – spirometry – bronchodliator responce.
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