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Ann Acad Med Stetin, 2006; 52, Suppl 1, 97-101

BARBARA STAWIARSKA-PIĘTA, EWA GRUCKA-MAMCZAR*, RAFAŁ STOJKO**, EWA BIRKNER*, JOLANTA ZALEJSKA-FIOLKA*

 

THE EFFECT OF SODIUM FLUORIDE AND CAFFEINE ON CONCENTRATIONS OF CALCIUM, PHOSPHORUS AND MAGNESIUM IN RAT SERUM

Katedra i Zakład Patologii Śląskiej Akademii Medycznej

ul. Ostrogórska 30, 41-200 Sosnowiec

Kierownik: prof. dr hab. n. med. Ewa Szaflarska-Stojko

* Zakład Biochemii Ogólnej Katedry Biochemii Śląskiej Akademii Medycznej

ul. Jordana 19, 41-808 Zabrze

Kierownik: dr hab. n. med. Ewa Birkner

** Katedra i Klinika Położnictwa i Ginekologii Śląskiej Akademii Medycznej

ul. Medyków 14, 40-752 Katowice

Kierownik: dr hab. n. med., prof. ŚAM Andrzej Witek

 

Summary

Purpose: The aim of this study was to examine the effect of sodium fluoride and caffeine on concentrations of calcium, phosphorus, and magnesium in rat serum.

Material and methods: The experiment was carried out in adult male Sprague–Dawley rats. Rats were divided into three groups of six rats. In the control group, animals received distilled water. In study group I, water was supplemented with sodium fluoride (4.9 mg F-/kg b.m./24 h), while study group II received sodium fluoride (4.9 mg F-/kg b.m./24 h) and caffeine (3 mg/kg b.m./24 h).

Results: Significantly higher calcium concentrations in serum were noted after exposure to NaF and caffeine. There was a tendency to higher levels of calcium in group I. Biochemical analysis of rat serum showed unchanged concentrations of magnesium and phosphorus vs. control. In conclusion, the dose of caffeine used by us had no effect on serum markers of mineral metabolism in hard tissues.

K e y w o r d s: NaF - caffeine - rats - serum - calcium - phosphorus - magnesium.

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